by David Sklar, Local Journalism Initiative Reporter
(AJNews) – For Dr. Brian Berkowitz, science has always been about asking difficult questions and refusing to accept conventional wisdom. The Edmonton-born scientist, now based at the Weizmann Institute of Science, has built an international career by challenging assumptions and applying scientific thinking in unexpected ways.
Speaking on the Chai There podcast, Berkowitz reflected on his journey from Alberta to Israel, where decades of research in hydrology, the study of water movement and groundwater systems, eventually led him into groundbreaking biomedical innovation.
After leaving Edmonton in 1982, Berkowitz said life in Israel encouraged the mindset he had always embraced. “I was always a rebel, always asking why, always dissatisfied with the way things were,” he said, explaining that true scientific progress often requires challenging accepted thinking.
That philosophy shaped his early career studying groundwater systems, where he developed a reputation for breakthrough research by rethinking how contaminants move underground. He credits part of that approach to lessons from his father, a respected Canadian chemist who taught him that real advances come from questioning even the most established experts.
But one of the biggest turning points in Berkowitz’s career came through a deeply personal experience. Several years ago, his son developed a severe kidney blockage that doctors believed would require removing the kidney. Refusing to accept that outcome, Berkowitz immersed himself in the field of urology, studying the problem and applying his expertise in fluid dynamics to search for alternatives.
After months of research and collaboration with doctors, he helped develop an experimental procedure that ultimately saved his son’s kidney. The experience opened an entirely new avenue of research. “I made my son three promises,” Berkowitz said. “That he wouldn’t lose his kidney, that I’d develop a painless ureteral stent, and that I’d figure out where kidney stones come from.”
That same cross-disciplinary thinking eventually led Berkowitz to lymphedema, a chronic condition caused by damage to the lymphatic system that results in painful fluid buildup in the limbs. Current treatments often rely on uncomfortable compression garments and repeated massage therapy, with limited long-term success.
Drawing on decades of hydrology research, Berkowitz and his team have developed a prototype “bionic lymph node,” a small implant designed to remove excess fluid and restore balance inside the body. The technology, now being advanced through his startup company Sub Q Bionics, could eventually improve the lives of millions worldwide.
For Berkowitz, the future of innovation depends on curiosity and collaboration. “There’s so much we don’t understand,” he said. “I love learning new things, so I feel I’m just getting started.”
Click below to listen to his conversation with Chai There podcast hosts David Sklar and Addie Borhaven.
The episode is available on
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Enjoy and Chai There!
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